About Super-depth Imaging Lab

Our lab has been a part of the Center for Molecular Spectroscopy and Dynamics, Institute for Basic Science in Korea since July 1, 2016. It also belongs to the Department of Physics, Korea University. The labs are located at the R&D center and Asan Science building, both in Korea University Seoul campus.

The laboratory aims to develop optical methodologies for imaging, sensing, and light manipulation of targets located deep within scattering media with their working depth beyond the level of conventional approaches. In particular, we are determined to solve inverse scattering problems at the microscopic level of scattering events and understand the physics of wave propagation inside scattering media. At the same time, we are expanding our studies to apply the developed methods for important biological and biomedical problems.

Representative papers for major research topics
  • Deep imaging within a complex medium

Through-skull brain imaging in vivo at visible wavelengths via dimensionality reduction adaptive-optical microscopy Science Advances 8, eabo4366 (2022)

- High-throughput volumetric adaptive optical imaging using compressed time-reversal matrix (Light: Science & Applications 11,16 (2022))

- Laser scanning reflection-matrix microscopy for aberration-free imaging through intact mouse skull (Nature Communications 11, 5721 (2020))

- Deep tissue space-gated microscopy via acousto-optic interaction (Nature Communications 11, 710 (2020))

- Deep optical imaging within complex scattering media (Nature Reviews Physics 2, 141 (2020))

- Label-free neuroimaging in vivo using synchronous angular scanning microscopy with single-scattering accumulation algorithm (Nature Communications 10, 3152 (2019))

- High-resolution adaptive optical imaging within thick scattering media using closed-loop accumulation of single scattering (Nature Communications 8, 2157 (2017))

- Imaging deep within a scattering medium using collective accumulation of single-scattered waves (Nature Photonics 9, 253 (2015))

  • Enhanced light energy delivery within/through a complex medium

- Focusing of light energy inside a scattering medium by controlling the time-gated multiple light scattering (Nature Photonics 12, 277 (2018)​​)

- Measurement of the time-resolved reflection matrix for enhancing light energy delivery into a scattering medium (Physical Review Letters 111, 243901 (2013))

- Maximal energy transport through disordered media with the implementation of transmission eigenchannels (Nature Photonics 6, 581 (2012))

- Transmission eigenchannels in a disordered medium (Physical Review B 83, 134207 (2011))

  • Transmission matrix approaches for endoscopy and nanoscopy 

Flexible-type ultrathin holographic endoscope for microscopic imaging of unstained biological tissues (Nature Communications 13, 4469 (2022))

- Near-field transmission matrix microscopy for mapping high-order eigenmodes of subwavelength nanostructures (Nature Communications 11, 2575 (2020))

- Control of randomly scattered surface plasmon polaritons for multiple-input and multiple-output plasmonic switching devices (Nature Communications 8, 14636 (2017))

- Scanner-free and wide-field endoscopic imaging by using a single multimode optical fiber (Physical Review Letters 109, 203901 (2012); Editor’s suggestion and highlighted with a viewpoint; Research highlight in Nature 491, 641 (2012))

- Overcoming the diffraction limit using multiple light scattering in a highly disordered medium (Physical Review Letters 107, 023902 (2011))

Super-depth Imaging Lab
Phone. +82-2-3290-3118 

Email. wonshik@korea.ac.kr

Korea University, 145 Anam-Ro, Seongbuk-Gu, Seoul 02841, Korea, 02841